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Innovators

Nanotechnology is needed to create devices that could diagnose and cure diseases by using targeting nano-medicines. This technology advance-ment could lower the pain of cancer therapy patients and increase the accuracy of treatment.

Cristal Therapeutics 

This is a is a clinical stage pharmaceutical company that develop nanoparticles to deliver drugs to tumor. Their most advanced drug is the docetaxel that treat breast, lung, prostate, stomach, head and neck cancer. CriPec medications consists of tuneable polymers and are designed and developed for targeting drugs. CriPec based products are nanomedicines that could possibly treat various disease such as cancer of inflammation. 
NEWS

Developing Drugs

  • CriPec docetaxel
    • Developing for treatment of solid tumors​
    • It works by interfering with cell division
    • It had a improved efficiency compared to Taxotere 
    • It could increase the survival time of certain patients
  • CriPec peptides
    • Their fast clearance associated with metabolic instability has hampered development
    • They might prevent burst release and undesired peak levels, protect peptides against degradation, and enable sustained systemic levels that allow for convenient dosing schedules.
  • CriPec dexamethasone
    • Treatment for Arthritis 
    • Extensive and sustained suppression of inflammation without corticosteroid-related adverse effects

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NanoBiotix

Nanobiotix is a nanomedicine company dedicated to the development of new treatments for cancer based on the combined application of nanotechnologies andbiotechnologies. It is a spin-off from the University of New York and it operates world-wide with it's base in Paris. Their very first technology, NanoXray contains nanoparticles that can enter tumor cells. In addition to an amount of radiation, it can destroy cancer cells and protect surrounding tissues as well.  

NanoXray 

Radiotherapy are widely used among cancer patients. However, there are still significant limitations to radiotherapy. NanoXray increases the X-ray dose absorption, without actually increasing the drug dose as to protect the surrounding cell tissues. NanoXray contains particles with hafnium oxide (HfO2) and has a high electron density enabling the absorption of energy provided by X-ray treatments.

Drugs in Trial

  • NBTXR3
    • It is a radio-enhancer that could be applicable in most solid tumor​s. 
    • Currently in clinical development
  • ​NBTXR3 – GEL
    • It can be applied directly to the tumor bed during the surgery after removing the tumor​
    • To prevent local or distant recurrence caused by any remaining cells.
  • ​NBTX-IV
    • A liquid containing crystalline hafnium oxide nanoparticles, surrounded with a special coating to improve bioavailability ​
    • Designed for injection to the tumor cell and surrounding the lymph node
A video about how NanoXray works

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CytImmune - Aurimune

Cytlmmune is a nanotherapy platform trying to develop safe and systematic drugs that can travel safely to the site of disease in the body and avoiding damaging nearby cells. The company's main strategy is to engineer gold nanoparticles targeted for tumor sites. Aurimune is a tumor targeted drug designed to travel safely to the tumor through vulnerable points. It then binds to certain receptors on in the blood vessels and release the drug substances that destroy the tumor’s nutritional support structures and protective barriers.
The Elements of Aurimune 

Drugs of Aurimune

  • CYT-6091
    • Carries TNF (Tumor Necrosis Factor) into tumors and disrupt their functions
    • TNF plays a role in regulating immune cells
    • CYT-6091 allows future chemotherapy to pass through the tumor and kill the cancer cells 
    • Successfully pass phase I clinical trial
  • CYT-21000
    • Second generation Aurimune nanomedicine
    • Carries Taxol (paclitaxel) in addition to TNF

The center of the Aurimune is a gold nanoparticle. PEG (PolyEthylene Glycol) is a water absorbing molecule that surrounds the gold nanoparticle. TNF (Tumor Necrosis Factor) breaks down the architecture of the blood vessels inside the tumor. 

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DNA Medicine Institute

The DNA Medicine Institute also known as DMI is a med-tech incubator, laboratory, and biomedical technology service provider. Products of this group are usually marketed through their partners or the spinoffs of DMI. Their partners include: NASA, National Institutes of Health, Bill & Melinda Gates Foundation, GigaDx LLC, National Instruments, Inc. and Pharma, Biotech, and Life Sciences companies. 

Platforms

DMI includes lots of different services that they are currently researching about:
  • Biomedical Engineering​
  • Physics and Biophysics
  • Nanofabrication
  • Microfluids
  • Medicine
  • Advanced Engineering
  • Genomics
  • 3D Printing

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Tarveda Therapeutics

The company's main approach is to develop drugs for cancer treatment. Their proprietary drug is Pentarins™ which is specialized to penetrate and eradicate tumor cells. Through the Pentarin platform the Tarveda team could further optimize to increase drug efficiency in the targeting of solid tumors. 

NEWS

September 29, 2016
Tarveda to Present at North American Neuroendocrine Tumor Society (NANETS) Symposium

September 19, 2016
Madrigal Pharmaceuticals and Tarveda Therapeutics Announce Exclusive License Agreement for HSP90 Drug Conjugate Oncology Platform

Pentarins™ Pipelines

  • PEN-221
    • Treat patients with neuroendocrine cancers and small cell lung cancer
    • It is expected to enter the clinic in 2016
    • A small drug containing a peptide ligand that is highly selective in targeting receptor SSTR2
  • PEN-866
    • It targets the intracellular protein HSP90
    • It is used to treat patients who are suffering from solid tumor cancers including colorectal cancer, small cell lung cancer and sarcoma 

Nanotherapeutics

This company focuses on manufacturing and developing biopharmaceutical drugs. It researches on nanoparticles for improving the performance of drug delivery by oral or nasal methods. It is said that their products has a broad applicability, could be used through multiple ways, high stability and a fairly obtainable manufacturing price. 

Pipelines

  • PREFLUCEL® 
    • An influenza vaccine​
    • Made from the Vero cell technology, which is a serum used to make influenza vaccine
    • PREFLUCEL® has been approved in 15 European countries and Brazil since 2010.
  • NTI-851 (Ramoplanin™)
    • A vaccine that kills bacteria for many gram-positive aerobic and anaerobic bacteria
  • NTC-510 (NanoBUP™)
  • NTC-942 (PRX-3140™)​
    • This drug is designed to cure Alzheimer's disease​ which 5% of the population aged 65-74 have the disease
    • Stimulates recognition and memory by activating protein receptor in the brain to release acetylcholine, a neurotransmitter that learns and memorize things
  • NTO-1151 (Triapine®)
    • A small molecule that inhibits the release ribonuclease reductase, an enzyme that replicates tumor cells
  • GelVac™ / GelSite®
    • An influenza vaccine that could enhance immune response

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Center for Nanomedicine (UC Santa Barbra)

UC Santa Barbra did researches on the following four diseases: ​
  • Sepsis
    • A deadly side effect due to bloodstream infection​
    • There are currently no medicines that could treat sepsis yet, but they discovered that a receptor system in the body could modulate sepsis
    • They are now currently working on drug targeting therapies that could control blood protein aging 
  • Type 1 and Type 2 Diabetes
    • Scientists from CNM suggested that Type 2 diabetes might be caused by cellular dysfunction 
    • The elimination of pancreatic beta cell in individuals with high fatty acids level further reduces the secretion of glucose-stimulated insulin
    • This important discovery provides a new approach to treat this deadly illness
  • Cancer
    • In cancer, cells lose control and grew rapidly. This results in tumor and cancer cells spreading in the body through a process called metastasis
    • Nanomedicines are used today to increase the effectiveness of cancer drugs and better eliminate tumor cells
    • CNM scientist have made nanoparticles that enables cancer drugs to enter tumors with increased infiltrating capabilities 
  • Autoimmune Diseases
    • Recent research discovered that​ glycan linkage present on cells control innate and adaptive immunity
    • They also found that autoimmune diseases results from aberrant glycan linkages that cause chronic inflammation
    • This discovery led to the establishment of mechanism autoimmune disease-associated pathology

Nanospectra

Nanospectra is a private company founded in 2002, focusing on the development of AuroLase®, which are nanoparticles that could be heat up to kill the tumor cells. They are now working on to improve the radiotherapy, lowering the damages of eyes from near-infrared laser and improving cancer images. 

Products

  • AuroLase Therapy
    • Combines AuroShell® particles with a near infrared laser​ to heat up the particles in order to destroy the tumor cells 
    • This technology allows the tumor cells to be quickly destroyed without damaging nearby cell tissues and also proved that there would cause no toxicity to the system
A further explanation of what is AuroLase

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